Effects of stratification in the analysis of affected-sib-pair data: benefits and costs.

doi:10.1086/302748

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Article

Effects of stratification in the analysis of affected-sib-pair data: benefits and costs.

American journal of human genetics - 1 Feb 2000

Leal S M, Ott J

Abstract excerpt

The benefits and costs of stratification of affected-sib-pair (ASP) data were examined in three situations: (1) when there is no difference in identity-by-descent (IBD) allele sharing between stratified and unstratified ASP data sets; (2) when there is an increase in IBD allele sharing in one of...

Topics

Age of Onset
Alleles
Chromosome Mapping
Genetic Diseases, Inborn
Genetic Heterogeneity
Genetic Linkage
Genetic Predisposition to Disease
Humans
Matched-Pair Analysis
Nuclear Family
Phenotype
Sample Size

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