Article
Detecting gene-gene interactions using affected sib pair analysis with covariates.
Human heredity - 1 Jan 2002
Holmans Peter
Abstract excerpt
Interest has recently focussed on allowing for interactions between loci as a way to increase power to detect linkage. In this paper, a simplified logistic regression method was used to perform affected sib pair analyses allowing for the inclusion of data from other loci. A systematic search of two-locus disease models was carried out to determine the situations in which this was advantageous. If IBD information...
Topics
- Genetic Linkage
- Genotype
- Lod Score
- Models, Genetic
- Models, Statistical
- Regression Analysis
- Software