Article
The bias introduced by population stratification in IBD based linkage analysis.
Human heredity - 1 Jan 2005
Wang Tao, Elston Robert C
Abstract excerpt
The lack of replication of model-free linkage analyses performed on complex diseases raises questions about the robustness of these methods to various biases. The confounding effect of population stratification on a genetic association study has long been recognized in the genetic epidemiology community. Because the estimation of the number of alleles shared identical by descent (IBD) does not depend on the...
Topics
- Bias
- Chromosome Mapping
- Founder Effect
- Genetic Diseases, Inborn
- Genetic Predisposition to Disease
- Genetics, Population
- Humans
- Quantitative Trait, Heritable
- Siblings