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Article

Commentary: the affected sib-pair method in the context of an epidemiologic study design.

Genetic epidemiology - 1 Jan 1991

Khoury M J, Flanders W D, Lipton R B, Dorman J S

Abstract excerpt

The purpose of this commentary is to provide a framework for using the well-known sib-pair methodology in the context of epidemiologic study designs. Using examples from the Pittsburgh family studies of insulin-dependent diabetes mellitus, we illustrate that the sib-pair method can be used in family-based epidemiologic studies. In a cohort study, unaffected relatives of probands ascertained from well-defined...

Topics

Alleles
Diabetes Mellitus, Type 1
Epidemiologic Methods
Family
Genetic Linkage
HLA Antigens
Haplotypes
Humans
Research Design
Risk Factors
Selection Bias

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1756950
DOI: 10.1002/gepi.1370080408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1756950-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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