Article
Use of unlinked genetic markers to detect population stratification in association studies.
American journal of human genetics - 1 Jul 1999
Pritchard J K, Rosenberg N A
Abstract excerpt
We examine the issue of population stratification in association-mapping studies. In case-control studies of association, population subdivision or recent admixture of populations can lead to spurious associations between a phenotype and unlinked candidate loci. Using a model of sampling from a structured population, we show that if population stratification exists, it can be detected by use of unlinked marker...
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