Efficiency of typing unaffected relatives in an affected-sib-pair linkage study with single-locus and multiple tightly linked markers.

Article

Efficiency of typing unaffected relatives in an affected-sib-pair linkage study with single-locus and multiple tightly linked markers.

American journal of human genetics - 1 Nov 1995

Holmans P, Clayton D

Abstract excerpt

In an affected-sib-pair study, the parents are often unavailable for typing, particularly for diseases of late onset. In many cases, however, it is possible to sample unaffected siblings. It is therefore desirable to assess the contribution of such siblings to the power of such a study. The likel...

Topics

Alleles
Genetic Diseases, Inborn
Genetic Linkage
Genetic Markers
Haplotypes
Humans
Likelihood Functions
Lod Score
Sample Size

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