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Article

Effects of age at onset on the power of the affected sib pair and transmission/disequilibrium tests.

Annals of human genetics - 1 May 2000

Li H, Hsu L

Abstract excerpt

Information on the age of a patient at disease onset, an important feature of complex diseases, is often collected in studies designed to map the disease genes. Penetrance-model-free methods, requiring no specification of penetrance functions, have been used extensively for detecting linkage and association between marker and disease loci. In this paper, we conduct an analytical study to examine the effects of...

Topics

Adult
Age of Onset
Aged
Aged, 80 and over
Female
Genetic Diseases, Inborn
Genetic Predisposition to Disease
Genetic Testing
Humans
Linkage Disequilibrium
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Genetic

Nuclear Family

Probability

Source

Identifiers

PMID: 11246475
DOI: 10.1017/S000348000000806X

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11246475-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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