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Article

Cost-effective sib-pair designs in the mapping of quantitative-trait loci.

American journal of human genetics - 1 May 1997

Zhao H, Zhang H, Rotter J I

Abstract excerpt

The extreme discordant-sib-pair design has been found to be the most powerful, across most genetic models. In this paper, we address two of the most frequently asked questions related to this design. First, under the extreme discordant-sib-pair design, a large number of people have to be screened for the phenotype of interest, before the desired number of discordant sibs can be collected for genotyping and...

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Identifiers

PMID: 9150169
PMCID: PMC1712450

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