Tests for covariate-associated heterogeneity in IBD allele sharing of affected relatives.

Abstract excerpt

Linkage studies that aim to map susceptibility genes for complex diseases commonly test for excess allele sharing among affected relatives. Conventional methods based on identical-by-descent IBD allele sharing do not allow for possible differences among families, such as arise in the case of locus heterogeneity, and thus have reduced ability to detect linkage in the presence of such heterogeneity. We investigated...

Topics

• Algorithms
• Alleles
• Family Health
• Genetic Heterogeneity
• Humans
• Inflammatory Bowel Diseases
• Linear Models
• Models, Genetic