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Article

Linkage analysis for diseases with variable age of onset.

Human heredity - 1 Jan 2000

Siegmund K D, Todorov A A

Abstract excerpt

We present a method for the multivariate linkage analysis of the age of onset of a disease. The approach allows the incorporation of covariates for the study of gene by environment interactions. It is applicable to general pedigrees. The likelihood of the data is expressed as a function of the number of alleles identical by descent at a marker, the censored ages of onset and disease status, and environmental...

Topics

Age of Onset
Aged
Alleles
Family Health
Female
Genes, Dominant
Genes, Recessive
Genetic Linkage
Genotype
Humans
Male
Middle Aged
Models, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Statistical

Source

Identifiers

PMID: 10686502
DOI: 10.1159/000022916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-10686502-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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