Analysis of affected sib pairs, with covariates--with and without constraints.

doi:10.1086/302288

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Article

Analysis of affected sib pairs, with covariates--with and without constraints.

American journal of human genetics - 1 Mar 1999

Greenwood C M, Bull S B

Abstract excerpt

Covariate models have previously been developed as an extension to affected-sib-pair methods in which the covariate effects are jointly estimated with the degree of excess allele sharing. These models can estimate the differences in sib-pair allele sharing that are associated with measurable envi...

Topics

Age of Onset
Alleles
Family
Genetic Linkage
Heterozygote
Humans
Lod Score
Models, Genetic
Models, Statistical
Penetrance
Statistics as Topic

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