Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice.

doi:10.1152/ajplung.1999.277.6.L1118

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Article

Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice.

The American journal of physiology - 1 Dec 1999

De Sanctis G T, Singer J B, Jiao A, Yandava C N, Lee Y H, Haynes T C, Lander E S, Beier D R, Drazen J M

Abstract excerpt

Quantitative trait locus (QTL) mapping was used to identify chromosomal regions contributing to airway hyperresponsiveness in mice. Airway responsiveness to methacholine was measured in A/J and C3H/HeJ parental strains as well as in progeny derived from crosses between these strains. QTL mapping of backcross [(A/J x C3H/HeJ) x C3H/HeJ] progeny (n = 137-227 informative mice for markers tested) revealed two...

Topics

Animals
Asthma
Bronchial Hyperreactivity
Bronchial Provocation Tests
Bronchoconstrictor Agents
Chromosome Mapping
Chromosomes
Genetic Linkage
Genotype
Male
Methacholine Chloride
Mice
Mice, Inbred A
Mice, Inbred C3H

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Open in PubMed

Identifiers

PMID: 10600881
DOI: 10.1152/ajplung.1999.277.6.L1118

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