Article
Airway hyperresponsiveness to acetylcholine: segregation analysis and evidence for linkage to murine chromosome 6.
American journal of respiratory cell and molecular biology - 1 May 1996
Ewart S L, Mitzner W, DiSilvestre D A, Meyers D A, Levitt R C
Abstract excerpt
A genetic predisposition to nonspecific airway hyperresponsiveness (AHR) can be demonstrated in humans and in many animal models. The goal of the current study was to gain insight into the molecular mechanisms that determine AHR by mapping the genes that control this phenotype. We describe genetic studies in a mouse model of differential sensitivity to acetylcholine (ACh)-induced AHR. This model was used to...
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