Article
Genetic interactions between chromosomes 11 and 18 contribute to airway hyperresponsiveness in mice.
PloS one - 1 Jan 2012
Ferreira Caroline M, Chen James L, Li Jianrong, Shimomura Kazuhiro, Yang Xinan, Lussier Yves A, Pinto Lawrence H, Solway Julian
Abstract excerpt
We used two-dimensional quantitative trait locus analysis to identify interacting genetic loci that contribute to the native airway constrictor hyperresponsiveness to methacholine that characterizes A/J mice, relative to C57BL/6J mice. We quantified airway responsiveness to intravenous methacholine boluses in eighty-eight (C57BL/6J X A/J) F₂ and twenty-seven (A/J X C57BL/6J) F₂ mice as well as ten A/J mice and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.