Article
The genetics of allergen-induced airway hyperresponsiveness in mice.
American journal of respiratory and critical care medicine - 1 Oct 1997
Wills-Karp M, Ewart S L
Abstract excerpt
Airway hyperresponsiveness (AHR) is a fundamental aspect of asthma that has been shown to be influenced by both environmental and genetic factors. Antigen sensitization and challenge of the A/J inbred mouse strain induced AHR, eosinophilic airway inflammation, and lung goblet cell hyperplasia. We discuss the evidence that supports the role of T helper cells and their subsets in determining the airway inflammatory...
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