Article
The genetics of allergen-induced airway hyperresponsiveness in mice.
American journal of respiratory and critical care medicine - 1 Oct 1997
Wills-Karp M, Ewart S L
Abstract excerpt
Airway hyperresponsiveness (AHR) is a fundamental aspect of asthma that has been shown to be influenced by both environmental and genetic factors. Antigen sensitization and challenge of the A/J inbred mouse strain induced AHR, eosinophilic airway inflammation, and lung goblet cell hyperplasia. We...
Topics
- Allergens
- Animals
- Asthma
- Bronchial Hyperreactivity
- Cell Differentiation
- Chromosome Mapping
- Crosses, Genetic
- Disease Models, Animal
- Interleukin-4
- Lymphocyte Activation
- Mice
- Mice, Inbred A
- Mice, Inbred C3H
- Phenotype
- Th1 Cells
- Th2 Cells