Article
Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice.
American journal of respiratory cell and molecular biology - 1 Oct 2000
Ewart S L, Kuperman D, Schadt E, Tankersley C, Grupe A, Shubitowski D M, Peltz G, Wills-Karp M
Abstract excerpt
Identification of the genetic loci underlying asthma in humans has been hampered by variability in clinical phenotype, uncontrolled environmental influences, and genetic heterogeneity. To circumvent these complications, the genetic regulation of asthma-associated phenotypes was studied in a murine model. We characterized the strain distribution patterns for the asthma-related phenotypes airway hyperresponsiveness...
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