Article
Interacting genetic loci cause airway hyperresponsiveness.
Physiological genomics - 21 Mar 2005
Ackerman Kate G, Huang Hailu, Grasemann Hartmut, Puma Chris, Singer Jonathan B, Hill Annie E, Lander Eric, Nadeau Joseph H, Churchill Gary A, Drazen Jeffrey M, Beier David R
Abstract excerpt
Airway hyperresponsiveness (AHR) is a key physiological component of asthma, and the genetic basis of this complex trait has remained elusive. We created recombinant congenic mice with increased naive AHR by serially backcrossing A/J mice (which have elevated naive AHR) with C57BL/6J mice and selecting for mice with an elevated naive AHR phenotype. The seventh backcross-generation hyperresponsive mice retained...
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