Article
Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice.
Nature genetics - 1 Oct 1995
De Sanctis G T, Merchant M, Beier D R, Dredge R D, Grobholz J K, Martin T R, Lander E S, Drazen J M
Abstract excerpt
Airway hyperresponsiveness is a key characteristic of human asthma and a marker for asthma-like conditions in animals. F1 mice derived from A/J and C57BL/6J display a phenotype which resembles the asthma-like phenotype of the A/J mice. Since airway responsiveness failed to segregate as a mendelian trait, we show significant linkage at two loci, Bhr1 (lod = 3.0) and Bhr2 (lod = 3.7) on chromosomes 2 and 15. A...
Topics
- Analysis of Variance
- Animals
- Asthma
- Chromosome Mapping
- Crosses, Genetic
- DNA
- Female
- Genetic Linkage
- Genotype
- Humans
- Kidney
- Lod Score