Article
Identification of novel chromosomal regions associated with airway hyperresponsiveness in recombinant congenic strains of mice.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2010
Camateros Pierre, Marino Rafael, Fortin Anny, Martin James G, Skamene Emil, Sladek Rob, Radzioch Danuta
Abstract excerpt
Airway responsiveness is the ability of the airways to respond to bronchoconstricting stimuli by reducing their diameter. Airway hyperresponsiveness has been associated with asthma susceptibility in both humans and murine models, and it has been shown to be a complex and heritable trait. In particular, the A/J mouse strain is known to have hyperresponsive airways, while the C57BL/6 strain is known to be...
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