Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lack of independent associations of apolipoprotein E promoter and intron 1 polymorphisms with Alzheimer's disease.

Neuroscience letters - 17 Sept 1999

Rebeck G W, Cheung B S, Growdon W B, Deng A, Akuthota P, Locascio J, Greenberg S M, Hyman B T

Abstract excerpt

Several studies have demonstrated genetic associations between Alzheimer's disease (AD) and polymorphisms in the promoter/enhancer regions of the apolipoprotein E (APOE) gene. These studies raise the possibility that APOE transcription control may be involved in altered risks for AD. We evaluated polymorphic sites in the intron-1 enhancer element (IE-1G/C) and in the APOE promoter (-219G/T). For the IE-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Apolipoprotein E2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein E4

Share to Apolipoproteins E

Share to Cerebral Amyloid Angiopathy

Share to Genetic Linkage

Share to Introns

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 10505604
DOI: 10.1016/s0304-3940(99)00602-3

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of independent associations of apolipoprotein E promoter and intron 1 polymorphisms with Alzheimer's disease.PMID 10505604Read ↗

Contribution of APOE promoter polymorphisms to Alzheimer's disease risk.Semantic proximity Read ↗

Effect of APOE genotype and promoter polymorphism on risk of Alzheimer's disease.Semantic proximity Read ↗

Apolipoprotein E -491 promoter polymorphism is an independent risk factor for Alzheimer's disease in the Chinese population.Semantic proximity Read ↗

No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population.Semantic proximity Read ↗

Genetic analysis of vascular factors in Alzheimer's disease.Semantic proximity Read ↗

Association of APOE promoter but not A2M polymorphisms with risk of developing Alzheimer's disease.Semantic proximity Read ↗

Independent association of an APOE gene promoter polymorphism with increased risk of myocardial infarction and decreased APOE plasma concentrations-the ECTIM study.Semantic proximity Read ↗

Lack of association between the interleukin-1alpha gene C(-889)T polymorphism and Alzheimer's disease in a Chinese population.Semantic proximity Read ↗

No association between polymorphisms in the neprilysin promoter region and Swedish Alzheimer's disease patients.Semantic proximity Read ↗

Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease.Semantic proximity Read ↗

APOE and APOC1 promoter polymorphisms and the risk of Alzheimer disease in African American and Caribbean Hispanic individuals.Semantic proximity Read ↗

The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.