Article
Association of APOE promoter but not A2M polymorphisms with risk of developing Alzheimer's disease.
Neuroreport - 9 Nov 2000
Halimi G, Duplan L, Bideau C, Iniesta D, Berthézène P, Oddoze C, Verdier J M, Michel B, Bergé-Lefranc J L
Abstract excerpt
The APOE4 allele is widely accepted as a major risk factor for late-onset Alzheimer's disease (AD). Recently, it has been reported that polymorphisms in the APOE promoter and in the alpha2-macroglobulin gene (A2M) are associated with AD. We have analyzed the distribution of APOE alleles, -219T/G APOE promoter polymorphism, and A2M/A2Mdel polymorphism in a large case-control study. Our results showed that APOE...
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