Article
Contribution of APOE promoter polymorphisms to Alzheimer's disease risk.
Neurology - 9 Jul 2002
Lambert J-C, Araria-Goumidi L, Myllykangas L, Ellis C, Wang J C, Bullido M J, Harris J M, Artiga M J, Hernandez D, Kwon J M, Frigard B, Petersen R C, Cumming A M, Pasquier F, Sastre I, Tienari P J, Frank A, Sulkava R, Morris J C, St Clair D, Mann D M, Wavrant-DeVrièze F, Ezquerra-Trabalon M, Amouyel P, Hardy J, Haltia M, Valdivieso F, Goate A M, Pérez-Tur J, Lendon C L, Chartier-Harlin M-C
Abstract excerpt
OBJECTIVE: To determine whether the effects of APOE promoter polymorphisms on AD are independent of the APOE-epsilon4 allele. BACKGROUND: Recently, the -491 A-->T and -219 G-->T polymorphisms located in the APOE promoter have been suggested to be risk factors for AD. However, the effects of these polymorphisms have not always been reproduced in case-control studies, possibly because of the strong linkage...
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