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Article

Independent association of an APOE gene promoter polymorphism with increased risk of myocardial infarction and decreased APOE plasma concentrations-the ECTIM study.

Human molecular genetics - 1 Jan 2000

Lambert J C, Brousseau T, Defosse V, Evans A, Arveiler D, Ruidavets J B, Haas B, Cambou J P, Luc G, Ducimetière P, Cambien F, Chartier-Harlin M C, Amouyel P

Abstract excerpt

Apolipoprotein E (APOE) is a major protein in lipid metabolism existing in three common isoforms: APOE2, -3 and -4. The varepsilon4 allele of the APOE gene ( APOE ) coding for the APOE4 isoform is associated with an increased risk of myocardial infarction (MI) and of Alzheimer's disease (AD). Recently, several polymorphisms in the APOE regulatory region have been reported. Some of these have been associated with...

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Source

Identifiers

PMID: 10587578
DOI: 10.1093/hmg/9.1.57

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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