Article
Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease.
Neuroscience letters - 23 Aug 2002
Boussaha Mekki, Hannequin Didier, Verpillat Patrice, Brice Alexis, Frebourg Thierry, Campion Dominique
Abstract excerpt
To date, allele 4 of the apolipoprotein E gene is the only risk factor that has been robustly associated with Alzheimer's disease (AD). Identification and molecular characterization of other risk factors is of great interest. The insulin degrading enzyme (IDE) is an attractive candidate gene since: (i), previous studies have identified a possible role that IDE plays in the degradation and clearance of human...
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