Article
Lack of association between the interleukin-1alpha gene C(-889)T polymorphism and Alzheimer's disease in a Chinese population.
Neuroscience letters - 5 Jun 2003
Tsai Shih-Jen, Liu Hsiu-Chih, Liu Tsung-Yun, Wang Kuang-Yih, Hong Chen-Jee
Abstract excerpt
Interleukin 1A (IL-1A), a potent proinflammatory cytokine, has been implicated in the pathogenesis of Alzheimer's disease (AD). Several recent studies have shown that a polymorphism in the IL-1A locus -889 was associated with AD risk and onset age, however, other studies were not able to replicate these findings. In this investigation, the IL-1A C(-889)T polymorphism has been analyzed for a Chinese population of...
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