Article
Effect of APOE genotype and promoter polymorphism on risk of Alzheimer's disease.
Neurology - 12 Dec 2000
Wang J C, Kwon J M, Shah P, Morris J C, Goate A
Abstract excerpt
OBJECTIVE: To verify the association between APOE gene promoter polymorphisms and the development of AD and to determine whether the effect of promoter polymorphisms on AD is independent of the APOE epsilon4 allele. BACKGROUND: Three polymorphisms in the APOE promoter have been shown to modify APOE expression in vitro. Several studies have suggested that these polymorphisms may also modulate risk for AD, either...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.