Article
The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease.
Neuroscience letters - 18 Dec 1998
Roks G, Cruts M, Bullido M J, Backhovens H, Artiga M J, Hofman A, Valdivieso F, Van Broeckhoven C, Van Duijn C M
Abstract excerpt
The -491 polymorphism in the promoter region of the apolipoprotein E gene (APOE) has been suggested to be associated with increased risk for Alzheimer's disease (AD) independent of APOE status. We studied the association between the -491 polymorphism and risk for early-onset Alzheimer's disease i...
Topics
- Age of Onset
- Alleles
- Alzheimer Disease
- Apolipoproteins E
- Chromosomes, Human, Pair 19
- Gene Frequency
- Genetic Linkage
- Genetic Testing
- Genotype
- Humans
- Linkage Disequilibrium
- Middle Aged
- Point Mutation
- Polymorphism, Genetic
- Regulatory Sequences, Nucleic Acid