Article
The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease.
Neuroscience letters - 18 Dec 1998
Roks G, Cruts M, Bullido M J, Backhovens H, Artiga M J, Hofman A, Valdivieso F, Van Broeckhoven C, Van Duijn C M
Abstract excerpt
The -491 polymorphism in the promoter region of the apolipoprotein E gene (APOE) has been suggested to be associated with increased risk for Alzheimer's disease (AD) independent of APOE status. We studied the association between the -491 polymorphism and risk for early-onset Alzheimer's disease in 99 Dutch and 78 Spanish patients. In patients with early-onset AD, we found no consistent relationship with a single...
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