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Article

Apolipoprotein E -491 promoter polymorphism is an independent risk factor for Alzheimer's disease in the Chinese population.

Neuroscience letters - 16 Oct 2003

Yang J D, Feng G Y, Zhang J, Cheung J, St Clair D, He L, Ichimura Keiichi

Abstract excerpt

Polymorphisms at positions -491, -427 and -219 in the promoter region of the Apolipoprotein E APOE gene have been variously reported to confer an increased risk of developing Alzheimer's disease (AD) independent of the effect of epsilon 2, 3 or 4 alleles in exon 4. In order to assess APOE promoter polymorphisms as independent risk factors in AD we have compared results in 183 definite or probable AD cases with...

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Source

Identifiers

PMID: 12962909
DOI: 10.1016/s0304-3940(03)00815-2

Genes

APOE
APOC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Apolipoprotein E -491 promoter polymorphism is an independent risk factor for Alzheimer's disease in the Chinese population.PMID 12962909Read ↗

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Apolipoprotein E promoter polymorphisms and risk of Alzheimer's disease: evidence from meta-analysis.Semantic proximity Read ↗

Effect of APOE genotype and promoter polymorphism on risk of Alzheimer's disease.Semantic proximity Read ↗

Apolipoprotein gene E4 allele promoter polymorphisms as risk factors for Alzheimer's disease.Semantic proximity Read ↗

Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals.Semantic proximity Read ↗

The -491A/T polymorphism of the Apolipoprotein E gene is associated with the ApoEepsilon4 allele and Alzheimer's disease.Semantic proximity Read ↗

Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene as risk factors for Alzheimer's disease.Semantic proximity Read ↗

The -491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism.Semantic proximity Read ↗

The -491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease.Semantic proximity Read ↗

Cerebral beta-amyloid deposition is augmented by the -491AA promoter polymorphism in non-demented elderly individuals bearing the apolipoprotein E epsilon4 allele.Semantic proximity Read ↗

ApoE -491A/T promoter polymorphism is not an independent risk factor, but associated with the epsilon4 allele in Hungarian Alzheimer's dementia population.Semantic proximity Read ↗

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