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Article

Mutational specificity in a shuttle vector replicating in chromium(VI)-treated mammalian cells.

Environmental and molecular mutagenesis - 1 Jan 1999

Liu S, Medvedovic M, Dixon K

Abstract excerpt

An SV40-based shuttle vector, pZ189, was used to characterize the mutation specificity and to explore the mechanism of chromium mutagenesis in mammalian cells. We showed previously that mutagenic DNA damage is induced by the treatment of plasmid with chromium(VI) plus glutathione in vitro. The induced mutation pattern suggested that chromium mutagenesis can be induced by the generation of reactive oxygen...

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PMID: 10398379
DOI: 10.1002/(sici)1098-2280(1999)33:4<313::aid-em8>3.0.co;2-v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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