Mutations induced in the supF gene of pSP189 by hydroxyl radical and singlet oxygen: relevance to peroxynitrite mutagenesis.

doi:10.1021/tx980008a

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Article

Mutations induced in the supF gene of pSP189 by hydroxyl radical and singlet oxygen: relevance to peroxynitrite mutagenesis.

Chemical research in toxicology - 1 May 1998

Jeong J K, Juedes M J, Wogan G N

Abstract excerpt

We previously showed that the oxidant peroxynitrite (ONOO-) was strongly mutagenic in the supF shuttle vector pSP189 replicated in bacteria or human cells. Qualitative characteristics of the mutational spectra induced by ONOO- differed significantly from those reportedly caused by hydroxyl radica...

Topics

Amino Acid Sequence
Base Sequence
Escherichia coli
Genes, Bacterial
Humans
Hydroxyl Radical
Molecular Sequence Data
Mutagens
Mutation
Nitrates
Plasmids
Reactive Oxygen Species
Transfection
Transformation, Bacterial

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