Article
Mutations induced by glyoxal and methylglyoxal in mammalian cells.
Nucleic acids symposium series - 1 Jan 2000
Murata-Kamiya N, Kamiya H, Kaji H, Kasai H
Abstract excerpt
To investigate the mutation spectra of glyoxal and methylglyoxal in mammalian cells, we analyzed mutations in a bacterial suppressor tRNA (supF) gene in the shuttle vector plasmid pMY189. The cytotoxicity and the mutation frequency increased according to the doses of glyoxal and methylglyoxal. The majority of glyoxal-induced mutations (65%) were base-pair substitutions, in which G:C-->C:G transversions were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.