Article
Molecular analysis of mutations induced by chemical carcinogens in mammalian cells. II. The use of recombinant DNA vectors.
Annali dell'Istituto superiore di sanita - 1 Jan 1994
Basic-Zaninovic T, Palombo F, Calcagnile A S, Dogliotti E
Abstract excerpt
One approach to molecular and mechanistic studies of mutagenesis in mammalian cells is to introduce a mutational target gene into the cells as part of a shuttle vector which is capable of replication in both mammalian cells and bacteria. Following mutagenesis in the mammalian cell host, the shuttle vector sequences are recovered from the mammalian cells and introduced into bacteria, where large amounts of the...
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