Sequence specificity of aflatoxin B1-induced mutations in a plasmid replicated in xeroderma pigmentosum and DNA repair proficient human cells.

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Article

Sequence specificity of aflatoxin B1-induced mutations in a plasmid replicated in xeroderma pigmentosum and DNA repair proficient human cells.

Cancer research - 15 Oct 1992

Levy D D, Groopman J D, Lim S E, Seidman M M, Kraemer K H

Abstract excerpt

The mutagenic spectrum induced by aflatoxin-DNA lesions in DNA repair deficient and repair proficient human cells was investigated. The reactive metabolite aflatoxin B1-8,9-epoxide was synthesized and reacted in vitro with the shuttle vector plasmid pS189. Plasmids were transfected into human fib...

Topics

Aflatoxin B1
Base Sequence
Cell Line, Transformed
DNA Repair
DNA Replication
DNA-Binding Proteins
Genetic Vectors
Humans
Molecular Sequence Data
Mutagenicity Tests
Mutation
Plasmids
Xeroderma Pigmentosum

Source

Open in PubMed

Identifiers

PMID: 1394191

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1394191-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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