Article
Mutagenesis by hydrogen peroxide treatment of mammalian cells: a molecular analysis.
Carcinogenesis - 1 Feb 1990
Moraes E C, Keyse S M, Tyrrell R M
Abstract excerpt
Hydrogen peroxide is an oxidizing agent which can be generated intracellularly either during normal metabolism or by treatment with external agents including solar UV radiation. Simian cells (CV-1) transfected with the SV40-based shuttle vector plasmid pZ189 have been treated with H2O2 and then incubated to allow repair and replication of the plasmid. The frequency of mutations at the supF locus of the recovered...
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