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Article

Sequence-dependent mutations in a shuttle vector plasmid replicated in a mismatch repair deficient human cell line.

Carcinogenesis - 1 Jul 1999

Tobi S E, Levy D D, Seidman1 M M, Kraemer1 K H

Abstract excerpt

We utilized a shuttle vector plasmid (pLSC) to assess the role of DNA sequence and mismatch repair on mutagenesis in human cells. pLSC contains an interrupted 29 bp mononucleotide poly(G) run within a bacterial suppressor tRNA gene, which acts as a highly sensitive mutagenic target for detection of base substitution and frameshift mutations. The frequency of spontaneous mutations in pLSC was found to be similar...

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Source

Identifiers

PMID: 10383903
DOI: 10.1093/carcin/20.7.1293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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