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Article

Copper-dependent site-specific mutagenesis by benzoyl peroxide in the supF gene of the mutation reporter plasmid pS189.

Carcinogenesis - 1 Oct 1992

Akman S A, Doroshow J H, Kensler T W

Abstract excerpt

Benzoyl peroxide (BzPO) enhances tumor promotion and malignant conversion in mouse epidermis. DNA damage may contribute to these processes. BzPO reacts with Cu(I) to produce the benzoyloxyl radical, which in turn causes strand breaks in plasmid DNA. In this study we investigated whether BzPO with or without Cu(I) caused promutagenic DNA damage in the supF gene of the mutation reporter plasmid pS189 replicating in...

Topics

Base Sequence
Benzoyl Peroxide
Cells, Cultured
Chromosome Mapping
Copper
DNA
DNA Damage
DNA Replication
Dimethyl Sulfoxide
Genes, Suppressor
Humans
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mannitol

Molecular Sequence Data

Mutagenesis, Site-Directed

Mutation

Plasmids

Source

Identifiers

PMID: 1423838
DOI: 10.1093/carcin/13.10.1783

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1423838-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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