Article

Characterizing cytosine methylation of polymorphic human transposable element insertions using human pangenome resources

2024-11-23

Abstract excerpt

Cytosine methylation, a crucial epigenetic modification, plays a vital role in genomic regulation. Leveraging the advancements in third-generation sequencing, we investigated the methylation patterns of non-reference insertions of human lymphoblastoid cell lines (LCLs), particularly polymorphic transposable elements (TEs). We validated the high concordance between long-read methylation calls and conventional whole...

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Literature Corpus work: 7a8d9fff-39f0-5278-98f4-41ccab06f9d5
DOI: 10.1101/2024.11.22.623804

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