Article

A comprehensive identification and annotation of mobile LINE-1 retrotransposons across human reference and personal genomes

2025-02-21

Abstract excerpt

LINE-1 (L1) is a type of mobile genetic element (retrotransposon) that can self-copy into distinct parts of its host genome by dynamically shaping its content. In humans, misregulation of these elements have been associated as the potential cause of distinct types of pathologies and neurodevelopmental disorders, including cancer, Rett syndrome and Aicardi Goutierrez disease. However, the precise annotation of thes...

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Literature Corpus work: f1d2f637-63da-59a4-898f-82cfd74d4c06
DOI: 10.1101/2025.02.17.638711

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