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Article

LINE-1 elements in structural variation and disease.

Annual review of genomics and human genetics - 1 Jan 2011

Beck Christine R, Garcia-Perez José Luis, Badge Richard M, Moran John V

Abstract excerpt

The completion of the human genome reference sequence ushered in a new era for the study and discovery of human transposable elements. It now is undeniable that transposable elements, historically dismissed as junk DNA, have had an instrumental role in sculpting the structure and function of our genomes. In particular, long interspersed element-1 (LINE-1 or L1) and short interspersed elements (SINEs) continue to...

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Identifiers

PMID: 21801021
DOI: 10.1146/annurev-genom-082509-141802
PMCID: PMC4124830

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