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Article

Immune signatures correlate with L1 retrotransposition in gastrointestinal cancers

2017-11-08

Abstract excerpt

<h4>ABSTRACT</h4> Long interspersed nuclear element-1 (L1) retrotransposons are normally suppressed in somatic tissues mainly by DNA methylation and antiviral defense. However, L1s can be desuppressed in cancers to act as insertional mutagens and cause genomic instability by creating DNA double strand breaks and chromosomal rearrangements. Whereas the frequency of somatic L1 insertions varies greatly among indivi...

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Literature Corpus work
659ac848-9ca9-50cc-91a6-336ca8e2bff6
DOI
10.1101/216051
Open publication

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Immune signatures correlate with L1 retrotransposition in gastrointestinal cancersDOI 10.1101/216051
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