Article

Active Human Transposable Elements: Long-Read Sequencing Technologies, Computational Analysis, and Implications for Human Disease

2026-07-15

Abstract excerpt

Transposable elements (TEs) constitute nearly half of the human genome and shape chromatin organization, gene regulation and genome evolution. We have large gaps in understanding their influence to physiology and pathology for now. In humans, the most active elements—LINE-1 (L1), Alu, and SVA retain some copies with the ability to evade epigenetic repression and mobilize via target-primed reverse transcription (TP...

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Literature Corpus work: 8dc4031c-1594-5006-bc2c-d1f4ea20ce34
DOI: 10.20944/preprints202607.1152.v1

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