Article

Cell type-specific prediction of 3D chromatin organization enables high-throughput <i>in silico</i> genetic screening

2022-03-07

Abstract excerpt

The mammalian genome is spatially organized in the nucleus to enable cell type-specific gene expression. Investigating how chromatin organization determines this specificity remains a challenge. Methods for measuring the 3D chromatin organization, such as Hi-C, are costly and bear strong technical limitations, restricting their broad application particularly in high-throughput genetic perturbations. In this study,...

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Literature Corpus work: 4d5de572-51cb-59df-992e-f8fff916a8bf
DOI: 10.1101/2022.03.05.483136

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