Article

Identification of copy number variations and translocations in cancer cells from Hi-C data

2017-08-21

Abstract excerpt

<h4>Motivation</h4> Eukaryotic chromosomes adapt a complex and highly dynamic three-dimensional (3D) structure, which profoundly affects different cellular functions and outcomes including changes in epigenetic landscape and in gene expression. Making the scenario even more complex, cancer cells harbor chromosomal abnormalities (e.g., copy number variations (CNVs) and translocations) altering their genomes both a...

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Literature Corpus work: cb6fb6ce-88e5-5519-aaa6-ffea0b29b4bd
DOI: 10.1101/179275

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