Article

PTEN is required for human Treg suppression of costimulation

2022-03-07

Abstract excerpt

Regulatory T cell (Treg) therapy is under clinical investigation for the treatment of transplant rejection, autoimmune disease, and graft-versus-host disease. With the advent of genome editing, attention has turned to reinforcing Treg function for therapeutic benefit. A hallmark of Tregs is dampened activation of PI3K-AKT signalling, of which PTEN is a major negative regulator. Loss-of-function studies of PTEN, ho...

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Literature Corpus work: ff9a9256-5935-5d95-9347-7b9ddec336cf
DOI: 10.1101/2022.03.06.483188

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