Article

Targeting of Cdc42 GTPase in regulatory T cells unleashes anti-tumor T cell immunity

2021-09-24

Abstract excerpt

Regulatory T (Treg) cells play an important role in maintaining immune tolerance through inhibiting effector T cell function. In the tumor microenvironment, Treg cells are utilized by tumor cells to counteract effector T cell-mediated tumor killing. Targeting Treg cells may thus unleash the anti-tumor activity of effector T cells. While systemic depletion of Treg cells can cause excessive effector T cell responses...

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Identifiers and source

Literature Corpus work: d5358a36-bb92-5718-8d85-f9a45c5ed648
DOI: 10.1101/2021.09.23.461402

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