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Article

Emerging role of PTEN loss in evasion of the immune response to tumours.

British journal of cancer - 1 Jun 2020

Vidotto Thiago, Melo Camila Morais, Castelli Erick, Koti Madhuri, Dos Reis Rodolfo Borges, Squire Jeremy A

Abstract excerpt

Mutations in PTEN activate the phosphoinositide 3-kinase (PI3K) signalling network, leading to many of the characteristic phenotypic changes of cancer. However, the primary effects of this gene on oncogenesis through control of the PI3K-AKT-mammalian target of rapamycin (mTOR) pathway might not be the only avenue by which PTEN affects tumour progression. PTEN has been shown to regulate the antiviral interferon...

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Source

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Identifiers

PMID: 32327707
DOI: 10.1038/s41416-020-0834-6
PMCID: PMC7283470

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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