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Article

CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions.

Cell reports - 31 Oct 2023

Ma Jingchang, Hu Wei, Liu Yitian, Duan Chujun, Zhang Dongliang, Wang Yuling, Cheng Kun, Yang Lu, Wu Shuwen, Jin Boquan, Zhang Yuan, Zhuang Ran

Abstract excerpt

Regulatory T (Treg) cells exhibit immunosuppressive phenotypes and particular metabolic patterns with certain degrees of plasticity. Previous studies of the effects of the co-stimulatory molecule CD226 on Treg cells are controversial. Here, we show that CD226 primarily maintains the Treg cell stability and metabolism phenotype under inflammatory conditions. Conditional deletion of CD226 within Foxp3+ cells...

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Identifiers

PMID: 37864795
DOI: 10.1016/j.celrep.2023.113306

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