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Article

Treg Destabilization and Reprogramming: Implications for Cancer Immunotherapy.

Cancer research - 15 Sept 2018

Munn David H, Sharma Madhav D, Johnson Theodore S

Abstract excerpt

Regulatory T cells (Tregs) are an important contributor to the immunosuppressive tumor microenvironment. To date, however, they have been difficult to target for therapy. One emerging new aspect of Treg biology is their apparent functional instability in the face of certain acute proinflammatory signals such as IL6 and IFNγ. Under the right conditions, these signals can cause a rapid loss of suppressor activity...

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Identifiers

PMID: 30181177
DOI: 10.1158/0008-5472.CAN-18-1351
PMCID: PMC6139039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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