Article

Activated PI3Kδ specifically perturbs mouse Treg homeostasis and function leading to immune dysregulation

2023-12-23

Abstract excerpt

Foxp3 + regulatory T cells (Treg) are required for maintaining immune tolerance and preventing systemic autoimmunity. PI3Kδ is required for normal Treg development and function. However, the impacts of dysregulated PI3Kδ signaling on Treg function remain incompletely understood. Here, we used a conditional mouse model of activated PI3Kδ syndrome (APDS) to investigate the role of altered PI3Kδ signaling specifical...

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Identifiers and source

Literature Corpus work: 6d081450-c0f6-530b-a66d-3fcf943c976f
DOI: 10.1101/2023.12.21.569665

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