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Article

An essential role for the IL-2 receptor in Treg cell function.

Nature immunology - 1 Nov 2016

Chinen Takatoshi, Kannan Arun K, Levine Andrew G, Fan Xiying, Klein Ulf, Zheng Ye, Gasteiger Georg, Feng Yongqiang, Fontenot Jason D, Rudensky Alexander Y

Abstract excerpt

Regulatory T cells (Treg cells), which have abundant expression of the interleukin 2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells. This feature indicates a key role for a simple network based on the consumption of IL-2 by Treg cells in their suppressor function. However, congenital deficiency in IL-2R results in reduced expression of the Treg cell lineage-specification factor Foxp3, which...

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Identifiers

PMID: 27595233
DOI: 10.1038/ni.3540
PMCID: PMC5071159

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